Patients tend to respond very well to topical steroid treatment. In one retrospective case series, the irritant was identified to https://tas71-bet.com/payments be endotoxin contaminating three vials of counterfeit bevacizumab. Similarly, in a non-counterfeit lot of bevacizumab, elevated levels of endotoxin and silicone oil residues contributed to a Canada-wide TASS outbreak (85). It is important to note that bevacizumab is used off-label for various ocular conditions, and the levels of both endotoxin and silicone oil in the lot met industry standards for intravenous use at that time. Despite the severity of intraocular inflammation in the setting anti-VEGF injections, the prognosis is often favorable (89).

If TASS develops, then there is usually a need for intraocular aqueous and vitreous tap for culture to rule out other diagnoses such as infection. In severe cases of TASS with persistent corneal edema, patients may need corneal transplantation. In refractory glaucoma, the eye pressure should be closely monitored. If the pressure is not responsive to medical management, glaucoma surgery may be necessary. TASS is a post surgical event after an anterior segment surgery.

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As with all cases of post-operative inflammation following cataract surgery, endophthalmitis must be considered. In the case presented here, there was a lower suspicion for endophthalmitis as symptoms were very acute in onset—within 24 hours of surgery, and the inflammation was predominantly anterior without evidence of vitritis. An additional characteristic of TASS includes limited description of pain from the patient; blurry vision predominates.

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Most TASS patients respond well to topical corticosteroids (such as 1% Prednisolone acetate) given hourly. Mild or early cases will respond to steroids rapidly as evidenced by clearing of the inflammation and decrease in intraocular pressure. In cases of moderate TASS, the clearing may take up to 3-6 weeks.

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